• Evaluering av helse, velferd og tilvekst hos steril laks etter embryonal blokkering av kimcellene 

      Andersen, Øivind; Tveiten, Helge; Thesslund, Tina; Kleppen, Hans-Petter (Research report; Forskningsrapport, 2022-04)
      Oppdrett av steril laks vil kunne redusere de negative interaksjonene mellom rømt oppdrettslaks og villaks, og dessuten forbedre fiskens velferd og kvalitet. Prosjektets hovedmål har vært å evaluere viktige produksjonsegenskaper hos steril laks etter å ha fjernet de embryonale kimcellene. Inaktivering av kimcellefaktoren Deadend ga livsvarig tap av kjønnsceller hos både hann- og hunnfisk. Steril ...
    • The genome sequence of Atlantic cod reveals a unique immune system 

      Star, Bastiaan; Nederbragt, Alexander Johan; Jentoft, Sissel; Grimholt, Unni; Malmstrøm, Martin; Gregers, Tone Fredsvik; Rounge, Trine Ballestad; Paulsen, Jonas; Solbakken, Monica Hongrø; Sharma, Animesh; Wetten, Ola Frang; Lanzén, Anders; Winer, Roger; Knight, James; Vogel, Jan-Hinnerk; Aken, Bronwen; Andersen, Øivind; Lagesen, Karin; Tooming-Klunderud, Ave; Edvardsen, Rolf; Kirubakaran, G. Tina; Espelund, Mari; Nepal, Chirag; Previti, A. Christopher; Karlsen, Bård Ove; Moum, Truls; Skage, Morten; Berg, Paul Ragnar; Gjøen, Tor; Kuhl, Heiner; Thorsen, Jim; Malde, Ketil; Reinhardt, Richard; Du, Lei; Johansen, Steinar Daae; Searle, Steve; Lien, Sigbjørn; Nilsen, Frank; Jonassen, Inge; Omholt, Stig W; Stenseth, Nils Christian; Jakobsen, Kjetill Sigurd (Journal article; Tidsskriftartikkel; Peer reviewed, 2011-08-10)
      Atlantic cod (Gadus morhua) is a large, cold-adapted teleost that sustains long-standing commercial fisheries and incipient aquaculture1, 2. Here we present the genome sequence of Atlantic cod, showing evidence for complex thermal adaptations in its haemoglobin gene cluster and an unusual immune architecture compared to other sequenced vertebrates. The genome assembly was obtained exclusively by 454 ...
    • Impacts of Early Life Stress on the Methylome and Transcriptome of Atlantic Salmon 

      Moghadam, Hooman; Johnsen, Hanne; Robinson, Nick; Andersen, Øivind; Jørgensen, Even Hjalmar; Johnsen, Helge K.; Bæhr, Vegar J.; Tveiten, Helge (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-10)
      Exposure to environmental stressors during early-life stages can change the rate and timing of various developmental processes. Epigenetic marks affecting transcriptional regulation can be altered by such environmental stimuli. To assess how stress might affect the methylome and transcriptome in salmon, fish were treated using cold-shock and air-exposure from the eye-stage until start-feeding. ...
    • Mucosal and systemic physiological changes underscore the welfare risks of environmental hydrogen sulphide in post-smolt Atlantic salmon (Salmo salar) 

      Lazado, Carlo C.; Stiller, Kevin Torben; Timmerhaus, Gerrit; Reiten, Britt Kristin Megård; Nicolaysen, Ilona Lorraine; Carletto, Danilo; Alipio, Hanna Ross De Dios; Hansen-Bergstedt, Julie; Andersen, Øivind (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-04)
      Atlantic salmon (Salmo salar) might encounter toxic hydrogen sulphide (H<sub>2</sub>S) gas during aquaculture production. Exposure to this gas can be acute or chronic, with heightened levels often linked to significant mortality rates. Despite its recognised toxicity, our understanding of the physiological implications of H<sub>2</sub>S on salmon remains limited. This report details the mucosal and ...
    • Production of sterile Atlantic salmon by germ cell ablation with antisense oligonucleotides 

      Tveiten, Helge; Andersen, Øivind; Swain, Jaya Kumari; Johnsen, Hanne; Mommens, Maren; Slanchev, Krasimir (Journal article; Tidsskriftartikkel, 2023)
      Cultivation of sterile-only fish in aquaculture offers multiple benefits of environmental, economical, and social value. A reliable method for efficient sterilization without affecting fish welfare and performance traits would have significant impact on fish production practices. Here, we demonstrate sterilization of Atlantic salmon embryos by targeting the dead end gene with antisense oligonucleotides. ...